Careers

About the Company

BriaCell Therapeutics is a clinical-stage immuno-oncology company developing novel cell-based immunotherapies for solid tumors, including metastatic breast cancer. Our mission is to advance innovative immunotherapy approaches that improve outcomes for patients with difficult-to-treat malignancies.

Bria-IMT™, BriaCell’s lead candidate, was awarded Fast Track status by FDA and is being evaluated in a pivotal Phase 3 combination study for metastatic breast cancer (MBC). MBC is breast cancer that has spread to other tissues. Bria-IMT™ is a targeted cell-based immunotherapy.

Bria-OTS™, a platform of personalized off-the-shelf cell-based immunotherapies, is being evaluated in a Phase 1/2 clinical study initially targeting breast cancer, with extension to prostate cancer, and other cancers.

Learn more at: BriaCell | Advancing Cancer Immunotherapy Treatment

About the Position:

We are seeking a motivated Research Associate / Senior Research Associate to join our research and development team in Philadelphia, PA. This position offers the opportunity to contribute to the development of novel cell-based immunotherapies in a dynamic, collaborative biotechnology environment.

The successful candidate will work closely with senior scientists and cross-functional teams to execute laboratory studies, support preclinical development activities, and contribute to the advancement of BriaCell's immuno-oncology pipeline. This is a hands-on laboratory position requiring strong technical expertise, independent problem-solving skills, and the ability to manage multiple priorities in a fast-paced environment.

Responsibilities

• Independently plan, execute, troubleshoot, and analyze laboratory experiments supporting the preclinical development of cell-based immunotherapeutic candidates.
• Perform in vitro studies using tumor cells, immune cells, and other relevant cellular models to evaluate therapeutic activity and biological mechanisms.
• Conduct immunological and cell-based assays, including multicolor flow cytometry, cytotoxicity assays, cytokine release assays, and cellular proliferation assays.
• Maintain and expand mammalian cell lines and primary cell cultures using established aseptic techniques.
• Support genetic engineering studies involving transfection, transduction, and other molecular biology techniques, as appropriate.
• Develop, optimize, and troubleshoot experimental protocols and analytical methods to improve assay performance, reproducibility, and reliability.
• Analyze experimental data, interpret results, identify trends, and communicate findings and recommendations to scientific leadership.
• Maintain accurate, complete, and timely laboratory records, experimental documentation, and data in accordance with established procedures and Good Documentation Practices.
• Collaborate with research, manufacturing, quality, and other cross-functional teams to support development objectives and project timelines.
• Contribute to the preparation of technical reports, scientific presentations, posters, manuscripts, and documentation supporting regulatory submissions.
• Assist in training and provide technical guidance to junior research associates, as needed.
• Support laboratory operations, including equipment maintenance, inventory management, reagent preparation, and compliance with laboratory safety procedures.

Qualifications:

Education and Experience

• Bachelor's or master’s degree in Immunology, Cell Biology, Molecular Biology, Biotechnology, or a related scientific discipline with 2 – 4+ years of relevant laboratory experience.
• Prior experience in biotechnology, biopharmaceutical research, or an academic research environment focused on immunology, oncology, or cell-based therapeutics.
• Demonstrated ability to independently execute experiments, troubleshoot technical challenges, and analyze complex scientific data.

Technical Skills and Knowledge

• Strong hands-on experience with mammalian cell culture, including established cell lines and primary cells.
• Proficiency in immunological and cell-based assays, including flow cytometry, cytotoxicity assays, cytokine release assays, and cell proliferation assays.
• Experience with experimental design, assay optimization, data analysis, and interpretation.
• Working knowledge of molecular biology techniques and cellular engineering approaches.
• Familiarity with laboratory documentation standards, experimental protocols, and scientific reporting.
• Proficiency with common laboratory data analysis and presentation tools.

Preferred Qualifications

• Experience in cell therapy, cancer immunotherapy, or immuno-oncology research.
• Hands-on experience with genetic engineering, transfection, and lentiviral transduction.
• Familiarity with Good Laboratory Practice (GLP), Good Manufacturing Practice (GMP), and Good Documentation Practices (GDP).
• Experience supporting preclinical development programs or preparing scientific documentation for regulatory submissions.

To apply, Please kindly send your resumes to careers@briacell.com

Equal Employment Opportunity Statement

BriaCell is an Equal Opportunity Employer. We are committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, pregnancy, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.

Third-Party Agency Statement

BriaCell does not accept unsolicited resumes or candidate submissions from search firms, staffing agencies, or other third-party recruiters without a signed agreement in place. Any unsolicited resumes submitted to BriaCell, its employees, or hiring managers will be considered the property of BriaCell, and no fees will be paid in the event the candidate is hired.

About the Company

BriaCell Therapeutics is a clinical-stage immuno-oncology company developing novel cell-based immunotherapies for solid tumors, including metastatic breast cancer. Our mission is to advance innovative immunotherapy approaches that improve outcomes for patients with difficult-to-treat malignancies.

Bria-IMT™, BriaCell’s lead candidate, was awarded Fast Track status by FDA and is being evaluated in a pivotal Phase 3 combination study for metastatic breast cancer (MBC). MBC is breast cancer that has spread to other tissues. Bria-IMT™ is a targeted cell-based immunotherapy.

Bria-OTS™, a platform of personalized off-the-shelf cell-based immunotherapies, is being evaluated in a Phase 1/2 clinical study initially targeting breast cancer, with extension to prostate cancer, and other cancers.

Learn more at: BriaCell | Advancing Cancer Immunotherapy Treatment

Position Summary

We are seeking an experienced, highly motivated Senior Scientist, Bioanalytical Development to support late-stage (Phase 3) bioanalytical method qualification and validation, and the continued development of our cell therapy programs and advancement of our analytical capabilities.

The Senior Scientist, Bioanalytical Development will develop, optimize, qualify, and transfer bioanalytical methods to support BriaCell’s clinical-stage cell therapy programs and future commercial manufacturing requirements.

This hands-on scientific position requires extensive experience in bioanalytical assay development, particularly multiparameter flow cytometry, cell-based potency assays, and analytical method qualification. The successful candidate will apply strong scientific judgment to characterize cell therapy products and evaluate critical quality attributes, including identity, purity, potency, and viability.

Working with Research and Development, Manufacturing, Quality Control, Quality Assurance, and external partners, this scientist will bridge development-stage assays with late-stage (Phase III) clinical and commercial analytical requirements.

Key Responsibilities

Bioanalytical Method Development and Optimization

• Independently design, develop, optimize, and execute bioanalytical assays for cell-based immunotherapies.
• Develop multiparameter flow cytometry methods, including panel design, gating strategies, controls, data acquisition, analysis, and troubleshooting.
• Develop and optimize cell-based functional and potency assays relevant to product biology and mechanism of action.
• Establish analytical methods for product identity, purity, potency, viability, and other critical quality attributes.
• Evaluate assay performance, variability, reproducibility, and robustness using appropriate experimental design and statistical analysis.
• Conduct laboratory experiments, interpret data, troubleshoot complex technical challenges, and recommend improvements.

Method Qualification, Validation, and Technology Transfer

• Lead or contribute to analytical method qualification, verification, and validation appropriate to intended use and stage of development.
• Develop and execute protocols evaluating relevant performance characteristics, including precision, accuracy, specificity, range, and robustness, as applicable.
• Define assay acceptance criteria, suitability requirements, controls, and critical reagent strategies.
• Lead analytical method transfers to internal QC teams, contract laboratories, and manufacturing partners, including comparative studies, troubleshooting, and transfer reports.
• Work with QC and QA to establish reliable, well-documented methods suitable for routine GMP use.

Clinical Development and Commercial Readiness

• Provide analytical support for product characterization, process development, comparability, and analytical control strategies.
• Develop or refine potency methods and other assays supporting late-stage clinical development and potential commercial manufacturing.
• Support analytical strategies for in-process controls, product release, stability, and characterization.
• Generate and interpret data and technical documentation supporting regulatory submissions and responses to health authority questions .
• Collaborate on critical quality attributes, analytical specifications, assay lifecycle management, and product comparability.

Scientific Collaboration and Technical Leadership

• Serve as a subject matter expert in flow cytometry, cell-based potency testing, and bioanalytical development.
• Collaborate with R&D, Process Development, Manufacturing, QC, QA, Regulatory Affairs, and external technical partners.
• Provide guidance and hands-on support to research associates and laboratory colleagues.
• Write analytical methods, protocols, technical reports, and scientific presentations; maintain accurate laboratory documentation.

Required Qualifications

• Master’s degree or PhD in Cell Biology, Immunology, Molecular Biology, Biochemistry, Biotechnology, Bioengineering, or a related scientific discipline.
• Minimum of 8 years of relevant biotechnology or biopharmaceutical laboratory experience, including substantial hands-on bioanalytical method development.
• Extensive experience designing, optimizing, troubleshooting, and qualifying biological analytical methods.
• Demonstrated expertise in multiparameter flow cytometry, including panel design, instrument operation, gating, analysis, and assay troubleshooting.
• Demonstrated experience developing and optimizing cell-based functional or potency assays.
• Experience with analytical method qualification and/or validation, including protocols, execution, performance evaluation, and technical documentation.
• Experience with mammalian cell culture and analytical methods relevant to cell therapies.
• Understanding of assay controls, reproducibility, analytical performance, and data interpretation.
• Experience supporting biological products through clinical development or toward commercial manufacturing.
• Ability to independently design and execute experiments, solve complex technical problems, and communicate results.

Preferred Qualifications

• Direct experience with cellular immunotherapies, cancer immunology, or advanced cell therapy products .
• Experience developing and qualifying potency assays for cell-based therapeutics.
• Experience with GMP-facing method transfer, validation, assay lifecycle management, and comparability assessments.
• Familiarity with ICH Q2(R2), ICH Q14, and applicable FDA expectations for cell therapy analytical controls.
• Experience interacting with contract testing laboratories or CDMOs and supporting late-stage clinical or commercialization programs.

To apply, Please kindly send your resumes to careers@briacell.com

Equal Employment Opportunity Statement

BriaCell is an Equal Opportunity Employer. We are committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, pregnancy, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.

Third-Party Agency Statement

BriaCell does not accept unsolicited resumes or candidate submissions from search firms, staffing agencies, or other third-party recruiters without a signed agreement in place. Any unsolicited resumes submitted to BriaCell, its employees, or hiring managers will be considered the property of BriaCell, and no fees will be paid in the event the candidate is hired.

About the Company

BriaCell Therapeutics is a clinical-stage immuno-oncology company developing novel cell-based immunotherapies for solid tumors, including metastatic breast cancer. Our mission is to advance innovative immunotherapy approaches that improve outcomes for patients with difficult-to-treat malignancies.

Bria-IMT™, BriaCell’s lead candidate, was awarded Fast Track status by FDA and is being evaluated in a pivotal Phase 3 combination study for metastatic breast cancer (MBC). MBC is breast cancer that has spread to other tissues. Bria-IMT™ is a targeted cell-based immunotherapy.

Bria-OTS™, a platform of personalized off-the-shelf cell-based immunotherapies, is being evaluated in a Phase 1/2 clinical study initially targeting breast cancer, with extension to prostate cancer, and other cancers.

Learn more at: BriaCell | Advancing Cancer Immunotherapy Treatment

About the Position

The QC Laboratory Manager oversees day-to-day Quality Control laboratory operations while personally performing GMP analytical testing supporting the manufacture and release of BriaCell Therapeutics’ investigational cell-based immunotherapy products. This working manager combines extensive scientific and technical experience with responsibility for laboratory personnel, resources, compliance, and timely test execution.

Reporting to the Senior Director, Quality Assurance, the position independently conducts and troubleshoots release assays; leads analytical method transfer from development or external laboratories into routine QC testing; and guides method qualification, verification, and validation appropriate to intended use. The manager partners with Manufacturing, Quality Assurance, Research and Development, and external testing providers to deliver reliable, documented test results and build scalable laboratory capabilities for late-stage clinical development and potential commercialization.

Responsibilities

Hands-on GMP Release Testing

• Personally perform and oversee routine and nonroutine in-process, product release, and stability testing, as applicable, using approved analytical methods and specifications
• Execute relevant assays for identity, purity, potency, viability, and other established quality attributes; techniques may include multiparameter flow cytometry, ELISA, cell-based functional/potency assays, and cell counting and viability methods.
• Prepare and handle samples, standards, controls, and reagents; assess assay suitability and test results against predefined criteria.
• Troubleshoot assay performance, atypical results, sample issues, and instrument problems; escalate potential product quality concerns promptly.
• Coordinate testing with manufacturing schedules to support timely clinical product release while maintaining data integrity and scientific rigor.

Analytical Method Transfer and Lifecycle

• Lead transfer of analytical procedures from R&D, analytical development, or outside laboratories into BriaCell’s GMP QC laboratory
• Assess method maturity and intended use; define sending/receiving laboratory responsibilities, risks, transfer strategy, equipment and material needs, staff training, and readiness criteria.
• Develop and execute approved method-transfer protocols with justified study design, samples, replicates, predefined acceptance criteria, deviation handling, and required documentation.
• Personally execute or directly oversee comparative testing and other scientifically appropriate transfer approaches; investigate method variability and technical gaps.
• Analyze transfer data; document discrepancies, conclusions, approvals, and readiness for routine testing in a final transfer report.
• Lead or support method qualification, verification, validation, and change-related reassessment as appropriate to the assay, development stage, and applicable requirements.

QC Laboratory Leadership and Operations

• Supervise, coach, train, and assign work to QC staff while retaining a meaningful personal laboratory testing workload
• Oversee sample receipt, chain of custody, testing plans, capacity, inventory, reagent management, reference standards, and laboratory workflow
• Ensure equipment qualification, calibration, preventive maintenance, instrument logs, and laboratory readiness are maintained
• Maintain and improve controlled testing procedures, laboratory records, equipment procedures, and efficient workflows.
• Monitor turnaround times, testing quality, assay trends, and resource needs; identify improvements that enable scale-up of late-stage clinical operations

GMP Compliance and Cross-functional Support

• Ensure testing and documentation comply with applicable cGMP, good documentation, and data integrity requirements
• Prepare, review, and approve technical QC documents and data within delegated authority and established independent-review controls.
• Lead scientific portions of OOS/OOT, atypical result, deviation, and assay-failure investigations, in collaboration with independent QA oversight; support CAPA and change control.
• Provide accurate release data and support Certificates of Analysis and other release packages; final product disposition remains with designated authorized Quality personnel.
• Support audits, inspections, regulatory documentation, contract testing laboratory oversight, and cross-functional problem solving.

Qualifications

• Bachelor’s or master’s degree in Biology, Cell Biology, Immunology, Biochemistry, Biotechnology, Molecular Biology, or another relevant scientific discipline; a PhD is not required.
• At least 7 years of relevant laboratory experience in biotechnology, biopharmaceuticals, or a closely related regulated setting, including extensive recent hands-on analytical testing experience.
• Substantial direct experience performing GMP release testing for biologics, cell therapies, or comparable complex biological products.
• Proven hands-on leadership of analytical method transfers, including planning, protocols, execution, acceptance criteria, troubleshooting, data evaluation, and transfer reports.
• Strong practical skills in relevant biological assays such as flow cytometry, immunoassays, cell-based potency/functional assays, and cell viability/count methods.
• Experience with analytical method qualification/verification/validation, GMP documentation, laboratory investigations, and data integrity.
• Experience overseeing laboratory operations and providing technical direction, training, or people supervision.
• Strong scientific judgment, technical troubleshooting, scheduling, communication, and ability to work in the lab while managing operational priorities.

Preferred Experience

Experience with allogeneic cell therapy, immuno-oncology products, or related advanced therapies.

Experience supporting Phase 3, commercial readiness, or scaling a small GMP QC laboratory

Familiarity with ICH Q2(R2), ICH Q14, USP <1224>, and relevant method transfer principles

Experience coordinating contract testing laboratories, regulatory inspections, LIMS, or electronic laboratory systems

To apply, Please kindly send your resumes to careers@briacell.com

Equal Employment Opportunity Statement

BriaCell is an Equal Opportunity Employer. We are committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, pregnancy, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.

Third-Party Agency Statement

BriaCell does not accept unsolicited resumes or candidate submissions from search firms, staffing agencies, or other third-party recruiters without a signed agreement in place. Any unsolicited resumes submitted to BriaCell, its employees, or hiring managers will be considered the property of BriaCell, and no fees will be paid in the event the candidate is hired.

Location: Philadelphia, PA / Onsite

About the Company:

BriaCell Therapeutics is a clinical-stage immuno-oncology company developing novel cell-based immunotherapies for solid tumors, including metastatic breast cancer. Our mission is to advance innovative immunotherapy approaches that improve outcomes for patients with difficult-to-treat malignancies.

Bria-IMT™, BriaCell’s lead candidate, was awarded Fast Track status by FDA and is being evaluated in a pivotal Phase 3 combination study for metastatic breast cancer (MBC). MBC is breast cancer that has spread to other tissues. Bria-IMT™ is a targeted cell-based immunotherapy.

Bria-OTS™, a platform of personalized off-the-shelf cell-based immunotherapies, is being evaluated in a Phase 1/2 clinical study initially targeting breast cancer, with extension to prostate cancer, and other cancers.

To apply, Please kindly send your resumes to careers@briacell.com

About the Position:

The Scientist, Translational Immunology & Biomarkers will play a key role in designing and executing biomarker and immune-monitoring strategies across BriaCell’s clinical immunotherapy programs. Working at the intersection of Research and Clinical Development, this scientist will characterize treatment-induced immune responses, evaluate pharmacodynamic biomarkers, and identify translational correlates associated with clinical activity.

This is a hands-on scientific role with responsibility for immunologic assay development and execution, clinical biomarker data analysis and interpretation, and scientific oversight of external laboratories and CROs. The Scientist will work closely with Research, Clinical Development, Clinical Operations, and Regulatory colleagues to translate biomarker findings into insights that inform clinical development of BriaCell’s cell-based immunotherapies

Responsibilities:

• Design and execute immunomonitoring and translational biomarker strategies across oncology clinical trials.
• Develop, optimize, troubleshoot, and execute immune-monitoring assays using clinical samples, including multiparameter flow cytometry, ELISpot/FluoroSpot, intracellular cytokine staining, T-cell functional assays, multiplex cytokine profiling, and humoral immune-response assays
• Coordinate and oversee clinical biomarker sample collection, processing, tracking, and analysis across PBMC, whole blood, serum/plasma, and tumor-tissue specimens.
• Analyze and interpret complex immunologic and biomarker datasets to characterize treatment-induced immune responses, pharmacodynamic activity, and translational correlates of clinical outcomes.
• Provide scientific oversight of CROs and specialty laboratories, including assay transfer/qualification, troubleshooting, study execution, and critical review of data and deliverables.
• Collaborate with Clinical Development, Clinical Operations, Research, and Regulatory colleagues to integrate biomarker findings into clinical-program strategy.
• Maintain rigorous experimental documentation and ensure high-quality, reproducible biomarker data.
• Communicate findings through scientific presentations, reports, and cross-functional program discussions.

Qualifications:

Required:

• PhD in Immunology, Cancer Biology, Molecular Biology, or a related field with 2–4+ years of relevant industry experience
  
• Strong background in immunology and immune monitoring
• Hands-on experience with flow cytometry, PBMC handling, ELISpot, and functional immune assays.
• Experience designing and optimizing of spectral flow cytometry panel
• Experience analyzing human translational or clinical biomarker data
• Strong organizational and analytical skills
• Comfortable working collaboratively in a team-oriented environment, with the ability to communicate effectively and contribute positively across functions.
• Knowledge of FlowJo, GraphPad Prism, and basic biomarker data analysis tools .

Preferred:

• Experience in immuno-oncology or oncology clinical development
• Familiarity with cancer vaccines, cell-based immunotherapies, or checkpoint inhibitor combinations
• Experience with CRO oversight and clinical biomarker workflows

To apply, Please kindly send your resumes to careers@briacell.com

Equal Employment Opportunity Statement

BriaCell is an Equal Opportunity Employer. We are committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, pregnancy, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.

Third-Party Agency Statement

BriaCell does not accept unsolicited resumes or candidate submissions from search firms, staffing agencies, or other third-party recruiters without a signed agreement in place. Any unsolicited resumes submitted to BriaCell, its employees, or hiring managers will be considered the property of BriaCell, and no fees will be paid in the event the candidate is hired.