Careers

About the Company

BriaCell Therapeutics is a clinical-stage immuno-oncology company developing novel cell-based immunotherapies for solid tumors, including metastatic breast cancer. Our mission is to advance innovative immunotherapy approaches that improve outcomes for patients with difficult-to-treat malignancies.

Bria-IMT™, BriaCell’s lead candidate, was awarded Fast Track status by FDA and is being evaluated in a pivotal Phase 3 combination study for metastatic breast cancer (MBC). MBC is breast cancer that has spread to other tissues. Bria-IMT™ is a targeted cell-based immunotherapy.

Bria-OTS™, a platform of personalized off-the-shelf cell-based immunotherapies, is being evaluated in a Phase 1/2 clinical study initially targeting breast cancer, with extension to prostate cancer, and other cancers.

Learn more at: BriaCell | Advancing Cancer Immunotherapy Treatment

About the Position

The QC Laboratory Manager oversees day-to-day Quality Control laboratory operations while personally performing GMP analytical testing supporting the manufacture and release of BriaCell Therapeutics’ investigational cell-based immunotherapy products. This working manager combines extensive scientific and technical experience with responsibility for laboratory personnel, resources, compliance, and timely test execution.

Reporting to the Senior Director, Quality Assurance, the position independently conducts and troubleshoots release assays; leads analytical method transfer from development or external laboratories into routine QC testing; and guides method qualification, verification, and validation appropriate to intended use. The manager partners with Manufacturing, Quality Assurance, Research and Development, and external testing providers to deliver reliable, documented test results and build scalable laboratory capabilities for late-stage clinical development and potential commercialization.

Responsibilities

Hands-on GMP Release Testing

• Personally perform and oversee routine and nonroutine in-process, product release, and stability testing, as applicable, using approved analytical methods and specifications
• Execute relevant assays for identity, purity, potency, viability, and other established quality attributes; techniques may include multiparameter flow cytometry, ELISA, cell-based functional/potency assays, and cell counting and viability methods.
• Prepare and handle samples, standards, controls, and reagents; assess assay suitability and test results against predefined criteria.
• Troubleshoot assay performance, atypical results, sample issues, and instrument problems; escalate potential product quality concerns promptly.
• Coordinate testing with manufacturing schedules to support timely clinical product release while maintaining data integrity and scientific rigor.

Analytical Method Transfer and Lifecycle

• Lead transfer of analytical procedures from R&D, analytical development, or outside laboratories into BriaCell’s GMP QC laboratory
• Assess method maturity and intended use; define sending/receiving laboratory responsibilities, risks, transfer strategy, equipment and material needs, staff training, and readiness criteria.
• Develop and execute approved method-transfer protocols with justified study design, samples, replicates, predefined acceptance criteria, deviation handling, and required documentation.
• Personally execute or directly oversee comparative testing and other scientifically appropriate transfer approaches; investigate method variability and technical gaps.
• Analyze transfer data; document discrepancies, conclusions, approvals, and readiness for routine testing in a final transfer report.
• Lead or support method qualification, verification, validation, and change-related reassessment as appropriate to the assay, development stage, and applicable requirements.

QC Laboratory Leadership and Operations

• Supervise, coach, train, and assign work to QC staff while retaining a meaningful personal laboratory testing workload
• Oversee sample receipt, chain of custody, testing plans, capacity, inventory, reagent management, reference standards, and laboratory workflow
• Ensure equipment qualification, calibration, preventive maintenance, instrument logs, and laboratory readiness are maintained
• Maintain and improve controlled testing procedures, laboratory records, equipment procedures, and efficient workflows.
• Monitor turnaround times, testing quality, assay trends, and resource needs; identify improvements that enable scale-up of late-stage clinical operations

GMP Compliance and Cross-functional Support

• Ensure testing and documentation comply with applicable cGMP, good documentation, and data integrity requirements
• Prepare, review, and approve technical QC documents and data within delegated authority and established independent-review controls.
• Lead scientific portions of OOS/OOT, atypical result, deviation, and assay-failure investigations, in collaboration with independent QA oversight; support CAPA and change control.
• Provide accurate release data and support Certificates of Analysis and other release packages; final product disposition remains with designated authorized Quality personnel.
• Support audits, inspections, regulatory documentation, contract testing laboratory oversight, and cross-functional problem solving.

Qualifications

• Bachelor’s or master’s degree in Biology, Cell Biology, Immunology, Biochemistry, Biotechnology, Molecular Biology, or another relevant scientific discipline; a PhD is not required.
• At least 7 years of relevant laboratory experience in biotechnology, biopharmaceuticals, or a closely related regulated setting, including extensive recent hands-on analytical testing experience.
• Substantial direct experience performing GMP release testing for biologics, cell therapies, or comparable complex biological products.
• Proven hands-on leadership of analytical method transfers, including planning, protocols, execution, acceptance criteria, troubleshooting, data evaluation, and transfer reports.
• Strong practical skills in relevant biological assays such as flow cytometry, immunoassays, cell-based potency/functional assays, and cell viability/count methods.
• Experience with analytical method qualification/verification/validation, GMP documentation, laboratory investigations, and data integrity.
• Experience overseeing laboratory operations and providing technical direction, training, or people supervision.
• Strong scientific judgment, technical troubleshooting, scheduling, communication, and ability to work in the lab while managing operational priorities.

Preferred Experience

Experience with allogeneic cell therapy, immuno-oncology products, or related advanced therapies.

Experience supporting Phase 3, commercial readiness, or scaling a small GMP QC laboratory

Familiarity with ICH Q2(R2), ICH Q14, USP <1224>, and relevant method transfer principles

Experience coordinating contract testing laboratories, regulatory inspections, LIMS, or electronic laboratory systems

To apply, Please kindly send your resumes to careers@briacell.com

Equal Employment Opportunity Statement

BriaCell is an Equal Opportunity Employer. We are committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, pregnancy, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.

Third-Party Agency Statement

BriaCell does not accept unsolicited resumes or candidate submissions from search firms, staffing agencies, or other third-party recruiters without a signed agreement in place. Any unsolicited resumes submitted to BriaCell, its employees, or hiring managers will be considered the property of BriaCell, and no fees will be paid in the event the candidate is hired.

Location: Philadelphia, PA Department: Research & Development / Quality Control

About the Company:

BriaCell Therapeutics is a clinical-stage immuno-oncology company developing novel cell-based immunotherapies for solid tumors, including metastatic breast cancer. Our mission is to advance innovative immunotherapy approaches that improve outcomes for patients with difficult-to-treat malignancies.

Bria-IMT™, BriaCell’s lead candidate, was awarded Fast Track status by the FDA and is being evaluated in a pivotal Phase 3 combination study for metastatic breast cancer (MBC). Bria-IMT™ is a targeted cell-based immunotherapy.

Bria-OTS™, a platform of personalized off-the-shelf cell-based immunotherapies, is being evaluated in a Phase 1/2 clinical study initially targeting breast cancer, with extension to prostate cancer and other cancers.

Learn more at: BriaCell | Advancing Cancer Immunotherapy Treatment

About the Position:

BriaCell Therapeutics is seeking an experienced Senior Scientist, Quality Control to play a key hands-on role in QC activities supporting our pivotal Phase 3 cell-based immunotherapy program and broader clinical pipeline. This individual will independently lead and execute analytical testing, assay qualification/validation, troubleshooting, data analysis, and QC documentation supporting product characterization, release, stability, and late-stage development.

This is a hands-on individual contributor role for an experienced QC scientist who is equally comfortable providing technical leadership and working at the bench. The Senior Scientist will independently own key QC activities while personally executing assays, investigating issues, interpreting data, and preparing required documentation. BriaCell operates with a small, highly collaborative team. Success in this position requires the ability to move fluidly between technical ownership, cross-functional collaboration, and day-to-day laboratory execution.

Responsibilities:

Quality Control Testing & Analytical Execution

• Lead and perform QC testing supporting in-process, characterization, release, and stability programs for clinical cell therapy products.
• Independently execute analytical methods including flow cytometry, ELISA, cell-based functional/potency assays, and other relevant QC methods
• Review analytical data for accuracy, completeness, compliance, and suitability for product disposition and development decisions.
• Ensure testing is performed in accordance with approved methods, specifications, SOPs, and applicable quality requirements.

Assay Development, Qualification & Validation

• Lead or independently execute development, optimization, qualification, validation, verification, and transfer of analytical methods used to characterize cell therapy products.
• Establish scientifically justified assay acceptance criteria and support development of specifications and qualification/validation strategies.
• Evaluate assay performance using appropriate statistical approaches, including precision, accuracy, linearity, robustness, variability, and reproducibility.
• Monitor and trend assay performance and identify opportunities to improve method robustness, consistency, and lifecycle control.

Investigations, Troubleshooting & Quality Systems

• Serve as a technical subject matter expert for complex assay troubleshooting and laboratory investigations.
• Lead or support OOS, OOT, deviation, and laboratory investigations, including root-cause analysis and scientifically sound corrective actions.
• Author, review, and maintain SOPs, analytical methods, qualification/validation protocols, technical reports, and investigation documentation.
• Maintain complete, accurate, and inspection-ready laboratory records in accordance with data integrity and quality expectations.
• Support CAPA, change control, and other quality-system activities as applicable.

Late-Stage Development & Regulatory Support

• Support QC activities associated with BriaCell’s pivotal Phase 3 program and future commercialization-readiness milestones.
• Contribute analytical and QC data to regulatory documentation, technical reports, and responses to regulatory requests.
• Support inspection readiness and participate as a QC technical SME during audits or regulatory interactions, as needed.
• Support analytical lifecycle activities related to cell banks, drug product, stability programs, and late-stage manufacturing.

Cross-Functional & External Collaboration

• Represent QC on cross-functional teams spanning R&D, Manufacturing, CMC, Quality, Regulatory, and Clinical functions.
• Partner with external testing laboratories and manufacturing organizations to support method transfer, technical troubleshooting, and review of externally generated QC data.
• Communicate analytical risks, assay performance issues, and recommendations clearly to scientific and cross-functional stakeholders.
• Provide technical guidance and mentorship to less-experienced scientists, where appropriate.

Qualifications:

• PhD in Immunology, Cell Biology, Biochemistry, Molecular Biology, or a related scientific discipline.
• 5+ years of relevant biotechnology or pharmaceutical industry experience; candidates with approximately 5–10 years of progressively responsible QC experience are particularly well aligned with this role.
• Hands-on expertise with flow cytometry and experience with cell-based functional/potency assays and/or ELISA
• Experience supporting GMP release and/or stability testing.
• Experience authoring and executing SOPs, analytical methods, qualification/validation protocols, and technical reports.
• Demonstrated ability to independently troubleshoot complex analytical assays and investigate performance issues.
• Strong understanding of statistical approaches used to evaluate assay performance, including precision, accuracy, variability, linearity, robustness, and reproducibility.
• Strong laboratory documentation practices, data integrity awareness, and attention to detail.

Preferred Qualifications

To apply, Please kindly send your resumes to careers@briacell.com

Equal Employment Opportunity Statement

BriaCell is an Equal Opportunity Employer. We are committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, pregnancy, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.

Third-Party Agency Statement

BriaCell does not accept unsolicited resumes or candidate submissions from search firms, staffing agencies, or other third-party recruiters without a signed agreement in place. Any unsolicited resumes submitted to BriaCell, its employees, or hiring managers will be considered the property of BriaCell, and no fees will be paid in the event the candidate is hired.

Location: Philadelphia, PA / Onsite

About the Company:

BriaCell Therapeutics is a clinical-stage immuno-oncology company developing novel cell-based immunotherapies for solid tumors, including metastatic breast cancer. Our mission is to advance innovative immunotherapy approaches that improve outcomes for patients with difficult-to-treat malignancies.

Bria-IMT™, BriaCell’s lead candidate, was awarded Fast Track status by FDA and is being evaluated in a pivotal Phase 3 combination study for metastatic breast cancer (MBC). MBC is breast cancer that has spread to other tissues. Bria-IMT™ is a targeted cell-based immunotherapy.

Bria-OTS™, a platform of personalized off-the-shelf cell-based immunotherapies, is being evaluated in a Phase 1/2 clinical study initially targeting breast cancer, with extension to prostate cancer, and other cancers.

To apply, Please kindly send your resumes to careers@briacell.com

About the Position:

The Scientist, Translational Immunology & Biomarkers will play a key role in designing and executing biomarker and immune-monitoring strategies across BriaCell’s clinical immunotherapy programs. Working at the intersection of Research and Clinical Development, this scientist will characterize treatment-induced immune responses, evaluate pharmacodynamic biomarkers, and identify translational correlates associated with clinical activity.

This is a hands-on scientific role with responsibility for immunologic assay development and execution, clinical biomarker data analysis and interpretation, and scientific oversight of external laboratories and CROs. The Scientist will work closely with Research, Clinical Development, Clinical Operations, and Regulatory colleagues to translate biomarker findings into insights that inform clinical development of BriaCell’s cell-based immunotherapies

Responsibilities:

• Design and execute immunomonitoring and translational biomarker strategies across oncology clinical trials.
• Develop, optimize, troubleshoot, and execute immune-monitoring assays using clinical samples, including multiparameter flow cytometry, ELISpot/FluoroSpot, intracellular cytokine staining, T-cell functional assays, multiplex cytokine profiling, and humoral immune-response assays
• Coordinate and oversee clinical biomarker sample collection, processing, tracking, and analysis across PBMC, whole blood, serum/plasma, and tumor-tissue specimens.
• Analyze and interpret complex immunologic and biomarker datasets to characterize treatment-induced immune responses, pharmacodynamic activity, and translational correlates of clinical outcomes.
• Provide scientific oversight of CROs and specialty laboratories, including assay transfer/qualification, troubleshooting, study execution, and critical review of data and deliverables.
• Collaborate with Clinical Development, Clinical Operations, Research, and Regulatory colleagues to integrate biomarker findings into clinical-program strategy.
• Maintain rigorous experimental documentation and ensure high-quality, reproducible biomarker data.
• Communicate findings through scientific presentations, reports, and cross-functional program discussions.

Qualifications:

Required:

• PhD in Immunology, Cancer Biology, Molecular Biology, or a related field with 2–4+ years of relevant industry experience
  
• Strong background in immunology and immune monitoring
• Hands-on experience with flow cytometry, PBMC handling, ELISpot, and functional immune assays.
• Experience designing and optimizing of spectral flow cytometry panel
• Experience analyzing human translational or clinical biomarker data
• Strong organizational and analytical skills
• Comfortable working collaboratively in a team-oriented environment, with the ability to communicate effectively and contribute positively across functions.
• Knowledge of FlowJo, GraphPad Prism, and basic biomarker data analysis tools .

Preferred:

• Experience in immuno-oncology or oncology clinical development
• Familiarity with cancer vaccines, cell-based immunotherapies, or checkpoint inhibitor combinations
• Experience with CRO oversight and clinical biomarker workflows

To apply, Please kindly send your resumes to careers@briacell.com

Equal Employment Opportunity Statement

BriaCell is an Equal Opportunity Employer. We are committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, pregnancy, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.

Third-Party Agency Statement

BriaCell does not accept unsolicited resumes or candidate submissions from search firms, staffing agencies, or other third-party recruiters without a signed agreement in place. Any unsolicited resumes submitted to BriaCell, its employees, or hiring managers will be considered the property of BriaCell, and no fees will be paid in the event the candidate is hired.