About BriaCell

Dedicated to enhancing the lives of women with breast cancer with limited therapy options, BriaCell Therapeutics Corp.’s (Nasdaq: BCTX, BCTXW) (TSX-V:BCT) mission is to develop novel immunotherapies to fight cancer. Immunotherapies have become the forefront of the cancer treatments because they use the body’s immune system to destroy cancer cells, offer the potential for higher levels of safety and efficacy than chemotherapy, and may also prevent cancer recurrence.

Collaboration with Incyte Corporation: BriaCell currently has a non-exclusive clinical trial collaboration with Incyte Corporation (Nasdaq:INCY) to evaluate the effects of combinations of novel clinical candidates. Under the agreement, Incyte and BriaCell will evaluate novel combinations of compounds from Incyte’s development portfolio with BriaCell’s drug candidates in advanced breast cancer patients.

BriaCell is conducting a Phase I/IIa clinical trial of Bria-IMT™, BriaCell’s lead candidate, in combination with the immunotherapy development candidates retifanlimab (INCMGA00012), an anti-PD-1 antibody, and epacadostat, an orally bioavailable small-molecule inhibitor of indoleamine 2,3-dioxygenase 1 (both provided by Incyte). The combination study is listed on ClinicalTrials.gov as NCT03328026.

Bria-OTS™*: BriaCell is developing Bria-OTS™, the first “off-the-shelf” personalized immunotherapy for the treatment for advanced stage breast cancer.

In November 2020, BriaCell announced a Cooperative Research and Development Agreement with the National Cancer Institute (NCI, Center for Cancer Research), part of the National Institutes of Health, to investigate the mechanism of action of novel off-the-shelf personalized therapeutics for cancer.

Small Molecule Program: BriaCell’s small molecule program consists of novel selective protein kinase C delta inhibitors that have shown activity in pre-clinical models of several cancers and fibrotic diseases.

* The continuation and completion of these studies depends on BriaCell securing adequate capital to execute these studies.


  • According to a report published by the American Cancer Society in 2021, approximately 608,570 Americans are expected to die from cancer in 2021 (approximately 1,670 deaths per day), making cancer the second leading cause of death in the U.S., exceeded only by heart disease.
  • As of January 2021, the number of women in the U.S. with a history of invasive breast cancer is estimated to be 3.1 million (excluding the estimated 284,200 new cases in 2021). This number is expected to increase by 12% to 4 million in 2024. Approximately 30% of breast cancers occur in women younger than age 50 and 44% occur in women older than age 65.
  • According to an American Cancer Society in 2021 fact sheet, 281,550 women and 2,650 men are expected to be diagnosed with invasive breast cancer in 2021 in the U.S. alone. Breast cancer is the most frequently-diagnosed cancer in women in the U.S.
  • Breast cancer deaths in 2021 are estimated to be 44,130 (43,600 women, 530 men), making breast cancer the second leading cause of cancer death in women (after lung cancer).
  • As reported by the American Cancer Society in 2021, approximately 62% of breast cancer cases are detected at the early stages (i.e., the cancer is found in the breast tissue, and has not spread to lymph nodes or other regions of the body), for which the 5-year survival rate is estimated to be 99%. As soon as the cancer spreads to lymph nodes under the arm or nearby tissues (regional stage), the 5-year survival rate drops to 85%. However, once the cancer spreads to other lymph nodes or body parts (distant stage or metastatic cancer), the 5-year survival rate falls to as low as 27% (i.e. 73% of the patients die within 5 years). This shows the significant need for effective treatments for this deadly cancer.