BriaCell is a clinical stage immuno-oncology company that is developing an entirely new class of targeted immunotherapies to transform cancer care
Under FDA approval of Bria-IMT™ combination pivotal study design in advanced metastatic breast cancer (i.e. breast cancer that has spread to other tissues). Awarded Fast Track status by the U.S Food and Drug Administration, Bria-IMT™ is being evaluated in a pivotal Phase 3 study for this disease
Bria-IMT™ a targeted cellular immunotherapy, and Bria-OTS™, a platform of personalized off-the-shelf cellular immunotherapies are under development in our fight against breast cancer and other cancers.
Bria-IMT™ has shown remarkable results thus far in clinical trials and has begun its pivotal Phase 3 registrational study.
How Bria-IMT™ and Bria-OTS™ Destroy Cancer Cells
BriaCell’s Patented Immunotherapy
Bria-IMT™
Bria-IMT™, our lead drug candidate, is a patented, off-the-shelf, cell based, targeted immunotherapy that stimulatesthe patient’s immune system to induce targeted killing of cancer cells.
Our data shows that Bria-IMT™, an off-the-shelf immunotherapy, expresses tumor antigens and granulocyte-macrophage colony-stimulating factor (GM-CSF) to activate specific cancer fighting CD4+ and CD8+ T cells, and stimulates the immune system to enhance targeted killing of cancer cells and when combined with a check point inhibitor “releases the brakes and steps on the gas” providing powerful anti-tumor activity.
BriaCell recently announced completion of enrollment of advanced breast cancer patients in its randomized ongoing Phase 2 combination study of Bria-IMT™ with Incyte’s immune checkpoint inhibitor, retifanlimab. This study followed successful completion of a Phase 1 study showing a favorable safety and efficacy profile for the combination regimen.
Off-The-Shelf Personalized Immunotherapy
Bria-OTS™
Our next generation personalized off-the-shelf immunotherapy, Bria-OTS™, awarded numerous US and international patents and supported by clinical data, forms the basis of BriaCell’s “OTS” strategy.
Introducing Bria-OTS™
- Bria-IMT™ is most effective in HLA – type matched patients
- Bria-OTS™ is engineered to express 15 unique HLA types through 4 independent cell lines
- Provides matched treatment to greater than 99% of patients with advanced breast cancer
- Simple saliva test determines patient HLA type for delivery of personalized off-the-shelf Bria-IMT™ immunotherapy
- Received a Small Business Innovation Research (SBIR) grant from the National Cancer Institute (NCI)
- Ongoing collaboration with the NCI
- Similar cell lines in development for prostate cancer (Bria-Pros™), lung cancer (Bria-Lung™), and melanoma (Bria-Me™) including enhanced ability to activate resting (naïve) T cells
BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXW; TSX: BCT) is a clinical stage immuno-oncology company that is developing an entirely new class of targeted cellular immunotherapies to transform cancer care
- Our lead drug candidate is Bria-IMT™. Developed by Dr. Charles Wiseman, and Dr. Alex Kharazi, Bria-IMT™ was designed to treat advanced metastatic breast cancer patients (i.e. patients in whom the cancer cells have spread beyond the breast) who did not respond to chemotherapies.
- According to American Cancer Society Facts and Figures, breast cancer is the most common cancer in the United States with 300,590 expected new cases in 2023.
- 43,700 women and men are expected to die of breast cancer in the U.S. in 2023, making breast cancer the 2nd leading cause of cancer death in women in the U.S.
- Immune Check Point Inhibitors (CPIs) work by neutralizing immune suppression that may be blocking the killing of cancer cells.
- Combining Bria-IMT™ with a CPI may significantly increase a patient’s immune system cancer fighting ability.
- Incyte (Nasdaq: INCY) → BriaCell has established a corporate collaboration and supply agreement with Incyte.
- Currently evaluating Bria-IMT™ in a pivotal Phase 3 combination study with an immune check point inhibitor.
- Bria-OTS™: BriaCell is developing a personalized “Off-The-Shelf” cellular immunotherapy based on a patient’s HLA-type.
- Experienced Management Team and Board of Directors; Clinical Strategy Team involved in 19 drug approvals.