Personalized Off-The-Shelf Immunotherapy
Bria-OTS™: Personalized Off-the-Shelf Immunotherapy
- We believe Bria-IMT™ is most effective in HLA – type matched patients
- Bria-OTS™ is engineered to express 15 unique HLA types in 4 independent cell lines
- Provides matched treatment to greater than 99% of patients with advanced breast cancer
- Simple saliva test determines patient HLA type for delivery of personalized off-the-shelf Bria-OTS™ immunotherapy
- Each patient will then be treated with the appropriate pre-manufactured Bria-OTS™ formulation
- This approach allows personalized treatment without the need for personalized manufacturing. Additionally, it saves time and skips expensive and complicated manufacturing procedures associated with other personalized immunotherapy treatments
- BriaCell received a Small Business Innovation Research (SBIR) grant from the National Cancer Institute (NCI) to further develop Bria-OTS™
- Ongoing collaboration with the NCI to investigate the Bria-OTS™ mechanism action
- BriaCell has secured numerous US and international patents for Bria-OTS™
- Similar cell lines in development for prostate cancer (Bria-Pros™), lung cancer (Bria-Lung™), and melanoma (Bria-Mel™) including enhanced ability to activate resting (naïve) T cells
Bria-OTS™: Off-the-Shelf Personalized Immunotherapy
BRIA-OTS™ IMMUNOTHERAPY COVERS ~99% OF THE BREAST CANCER POPULATION
The study is listed on ClinicalTrials.gov as NCT06471673.